Cassava is a major staple worldwide and cultivated in a marginal to nutrient rich soil. However, there are varietal differences in cassava productivity across locations thereby reducing productivity, which has necessitated the continual development of new varieties that are more stable at different environments. This study thus assessed the growth and yield, and nutrient changes of three newly released and 2 old cultivated cassava varieties in the grown environment. The five varieties were planted out in a randomized complete block design with three replicates. Pre and varietal-post soil physic-chemical parameters were assessed using standard procedures. Data were taken on the plant height (PH), leaf area (LA), number of roots tubers (NOR), tuber weight (TW), and changes in macro and micro elements. All data were analysed using descriptive statistics and analysis of variance, while means were separated using least significant differences at 5% significance level.  The PH, and LA differed significantly between varieties and ranged from 31.67±1.90 (TME-419) to 45.67±1.90 cm (Give-me-chance), 42.82±4.14 cm2 (Game changer) to 58.85±4.14 cm2 (TME-419). The NOR and RW ranged from 3.00±0.73 (Nwaugo) to 5.33±0.73 (TME-419), and 441.7±253.01 g (Give-me-chance) to 1533.30±253.01 (TME-419 and Game changer). The changes in nitrogen, phosphorus, calcium, magnesium and potassium ranges from -0.11 (Give-me-chance-plots) to 0.11 (Game changer-plots), -5.62 (TME-419-plots) to 10.37 (Hope-plots), -0.51 (Give-me-chance-plots) to 0.47 (TME-419-plots), -0.16 (Game changer-plots) to 012 (TME-419), and from -0.06 (Hope-plots) to 0.14 (TME-419-plots), respectively. Newly released varieties produced heavier tubers released varieties relative to the old varieties which depleted more soil nutrients.