The field experiment was conducted in an agricultural field north of Babylon Governorate in the spring of 2023 to study the effect of soil fertilization with zinc and copper nano-fertilizers. Potatoes (Solanum tuberosum) Arizona type were used in the experiment, and the study groups were as follows: G1: Control (0% Cu and Zn), G2: Control + sprays of water, G3: sprays of 2.5% Cu, G4: sprays of 5% Cu, G5: sprays of 2.5% Zn, G6: sprays of 5% Zn. The results shown: the G5 and G6 groups recorded the highest plant height in all study periods 30, 60 and 90 days, A significant increase was observed for all groups treated with fertilization in the number of leaves per plant, plant branches per plant and days taken for 50% flowering and number of tubers per plant compared to the control groups.